By then, George Anemogiannis was already a renowned scenographer who decided to broaden his collaborations. He designed costumes and settings for the majority of theatre companies of Athens among which the troupes of Katerina, Anna-Maria Kalouta, Papa-Lambeti-Horn and others, whereas he also continued working for the National Opera and the Kotopouli theatre company. Actually, in 1950, he collaborated with the latter on the play "Anna of the 1000 days", by Dimitris Myrat, starring some of the most important actors of this period: Melina Merkouri, Irene Pappa, Anna Synodinou, Nitsa Tsaganea, Christos Tsaganeas, Dimitris Myrat, Titos Vandis, Ntinos Iliopoulos, Mimis Fotopoulos and many others.
In the early 50s, the presence of Sophia Vembo, who culminated in the light music theatre, became the cornerstone of his career. Initially, he hesitated accepting her offer to collaborate, but her insistence along with the mediation of Marika Kotopouli made him change his mind and accept. Therefore, in the summer of 1951 they presented together the play "Heave up the anchors!". It was the first play with three impressive curtains instead of only one, and the first time a play had regular theatrical projectors. It was a landmark show for Greek variety theatre, with a huge success, and it was the first to introduce spectacular theatrical shows.
Although he did not abandon prose plays, from that point onwards, Anemogiannis dedicated himself to light music theatre. After working for some more time with Vembo, he collaborated for many years with Vasilis Bournelis, with whom he created some of the most unforgettable variety shows at Acropol Theatre.